Bioactive Small Molecules
Cayman Chemical ANTIBODY KIN1148 5mg
An IRF3 activator and adjuvant; increases the mRNA expression of the genes encoding ISG54 and OASL in PH5CH8 cells and increases CXCL10 production in phorbol 12-myristate 13-acetate-differentiated THP-1 monocytes at 10 µM; immunization with a vaccine in combination with KIN1148 increases blood IgG, neutralizing, and hemagglutinin antibody titers, decreases PFUs in the lungs and lung-draining lymph nodes, and increases the survival percentage of mice infected with a lethal dose of influenza virus when used as an adjuvant
Medchemexpress LLC Hydrazine, (1-methyl-2-phenylethyl)-, hydrochloride | 66-05-7 | 98.7% | 186.68 g/mol | C9H15ClN2 | 25 MG
Pheniprazine hydrochloride is the hydrochloride salt of pheniprazine, a potent, long-acting monoamine oxidase (MAO) inhibitor used as a research reagent for studies of MAO function and depression models. The compound is supplied as a white to off-white solid suitable for laboratory use.
- Potent, long-acting MAO inhibitor.
- Used in research on depression and monoamine neurotransmitter systems.
- Supplied as a white to off-white solid powder for laboratory handling.
- High purity (≈98.7%) for analytical and experimental consistency.
- Molecular weight 186.68 g/mol; formula C9H15ClN2.
- Available in small research quantities and as a DMSO solution vial.
Cayman Chemical ML-00253764hydrochlorIde 5mg
A MC4R antagonist (Ki = 0.16 µM); selective for MC4R over MC3R and MC5R (IC50s = 0.32, 0.81, and 2.12 µM, respectively); decreases cAMP production induced by [NDP]-α-MSH by 20% in MCR4-expressing HEK293 cell membranes, but has no effect on cAMP levels in MC3R- or MC5R-expressing HEK293 cell membranes at 100 µM; prevents the loss of lean body mass and enhances light-phase food consumption in a LLC mouse xenograft model but does not reduce tumor size at 15 mg/kg
![Medchemexpress LLC 12-ethyl-4-methyl-11-(propan-2-yl)-1,8,10-triazatricyclo[7.4.0.0²,⁷]trideca-2(7),3,5,8,11-pentaen-13-one | 2641398-04-9 | MFCD35078192 | 99.9% | C16H19N3O | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261905.png-250.jpg)
Medchemexpress LLC 12-ethyl-4-methyl-11-(propan-2-yl)-1,8,10-triazatricyclo[7.4.0.0²,⁷]trideca-2(7),3,5,8,11-pentaen-13-one | 2641398-04-9 | MFCD35078192 | 99.9% | C16H19N3O | 10MG
MrgprX2 antagonist-4 is a small-molecule antagonist of the human MRGPRX2 receptor intended for preclinical research into mast cell-driven inflammatory skin disorders and pseudo-allergic reactions. It is supplied for in vitro and in vivo studies and is not for human therapeutic use.
- High purity suitable for research (99.9% reported).
- Molecular formula C16H19N3O; molecular weight 269.34 g·mol⁻¹.
- Soluble in DMSO; in vitro solubility ~5 mg/mL with warming and sonication.
- In vivo formulation: 10% DMSO in corn oil (clear solution ≥0.5 mg/mL).
- Intended for laboratory research use only, not for clinical use.
- Useful tool compound for studies of mast cell degranulation and skin inflammation.
Cayman Chemical ANTIBODY M50054 1mg
A cell-permeable inhibitor of caspase-3 activation; blocks apoptosis in a variety of cell lines induced by different stimuli, including Fas ligand and etoposide
Medchemexpress LLC Pseudomonas quinolone signal (PQS) | 108985-27-9 | 99.8% | 10 MG
Pseudomonas quinolone signal (PQS) is a quorum-sensing signaling molecule produced by Pseudomonas aeruginosa. Its synthesis depends on the las quorum-sensing system, and its biological activity is linked to the rhl system. PQS regulates the expression of the virulence gene lasB. It also plays roles in iron acquisition, cytotoxicity, outer-membrane vesicle biogenesis, and host immune modulation.
- Can induce expression of the lasB-lacZ fusion gene and activate β-galactosidase activity in P. aeruginosa strain PAO-R1 (lasR⁻) (pTS400) in vitro.
- Promotes synthesis of pyochelin and pyocyanin, increases bacterial sensitivity to H2O2, and reduces iron concentration in the culture medium in P. aeruginosa PAO1 in vitro.
Cayman Chemical ANTIBODY MG-BSA 200ug
Source: Albumin isolated from bovine plasma and modified with methylglyoxal Unmodified BSA • MW: 69.3 kDa
Medchemexpress LLC L-692429 (mk-0751) | 145455-23-8 | 99.9% | 509.60 | 5 G
L-692429 (MK-0751) is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist that binds to G protein-coupled receptors with a Ki of 63 nM. This product is for research use only. It stimulates intracellular calcium release, inositol phosphate (IP) turnover, cAMP-responsive element binding protein (CREB) activity, serum-responsive element activity, and bioluminescence resonance energy transfer (BRET) activity. L-756867 inhibits L-692429-stimulated GH secretion in anesthetized rats.
- Binds to G protein-coupled receptors
- Stimulates intracellular calcium release (EC50: 26 nM)
- Stimulates IP turnover (EC50: 47 nM)
- Stimulates CREB activity (EC50: 60 nM)
- Stimulates SRE activity (EC50: 63 nM)
- Stimulates BRET activity (EC50: 58 nM)
- Activates MAPK pathway in hela-T4 cells
- Inhibits GH secretion in anesthetized wistar rats
Cayman Chemical ANTIBODY RO4987655 25mg
A MEK inhibitor (IC50 = 5 nM); selective for MEK over 400 kinases at 10 µM; inhibits proliferation of COLO 205, HT-29, QG56, MIA PaCa-2, and C32 cells (IC50s = 0.86, 1.7, 9.5, 3.3, and 8.4 nM, respectively); reduces tumor growth in a variety of mouse xenograft models; inhibits the phosphorylation of ERK in tumor tissue in an HT-29 mouse xenograft model at 6.25 mg/kg per day; acts synergistically with everolimus to reduce tumor volume in an HCT116 mouse xenograft model
TARGETMOL CHEMICALS INC PU.1-IN-1 10MG
Also available in 25 mg 50 mg and bulk. Please contact Fisher for quotes. PU.1-IN-1 is a potent PU.1 inhibitor (IC50 2 nM) with anti-inflammatory activity. purity: 98%
Cayman Chemical ANTIBODY SB-3CT 1mg
A selective, mechanism-based inhibitor of MMP-2 and MMP-9 (Kis = 28 and 400 nM, respectively); a monohydroxylated metabolite has greater inhibitory activity (Kis = 6 and 160 nM for MMP-2 and MMP-9, respectively); can cross the blood-brain barrier
![Medchemexpress LLC (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one | 1197420-05-5 | 99.8% | 468.95 g/mol | C24H21ClN2O4S | 5MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000237915.png-250.jpg)
Medchemexpress LLC (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one | 1197420-05-5 | 99.8% | 468.95 g/mol | C24H21ClN2O4S | 5MG
BMS-819881 is a research-use melanin-concentrating hormone receptor 1 (MCHR1) antagonist supplied as a small-quantity solid for in vitro and preclinical studies. The compound has molecular formula C24H21ClN2O4S, molecular weight 468.95 g/mol, and CAS 1197420-05-5. Storage and solubility guidance are provided by the supplier; the material is intended for laboratory research only and is not for clinical use.
- Molecular formula C24H21ClN2O4S.
- Molecular weight 468.95 g/mol.
- CAS registry number 1197420-05-5.
- Purity 99.8% as supplied.
- Available in small vial sizes suitable for solution preparation.
- Storage: powder stable at -20°C (3 years) or 4°C (2 years); in solvent store at -80°C (6 months) or -20°C (1 month).
- Solubility: ≥ 2.5 mg/mL in 10% DMSO/corn oil; clear solution at this concentration.
- For research use only; not for human or clinical use.
Selleck Chemical LLC Tafamidis meglumine E4852-100MG
Tafamidis meglumine (Vyndaqel Fx-1006A) stabilizes the tetrameric structure of transthyretin (TTR) by binding to thyroxine-binding sites Tafamidis meglumine treats transthyretin familial amyloid polyneuropathies (TTR-FAP) a condition characterized by neurological damage from TTR amyloidosis by preventing the misfolding and aggregation of transthyretin (TTR) into amyloid fibrils
Cayman Chemical ANTIBODY Ro 67-7476 1mg
A positive allosteric modulator of mGluR1; enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 μM); selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at 10 μM; increases the amplitude of mGluR1 EPSCs evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices; activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM)
Medchemexpress LLC L803-mts (Myristoylated L 803) | 706785-93-5 | 98.7% | 1465.63 | 5 MG
L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM). It reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts also shows an antidepressive effect in the forced swimming test.
- Selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM)
- Reduces Aβ deposits
- Ameliorates cognitive deficits in 5XFAD mice
- Shows antidepressive effect in the forced swimming test