Bioactive Small Molecules
Medchemexpress LLC O=C(NC1=CC=C(C=C1)C#C)C2=C3N=C(C=C(N3N=C2)C)C | 1380716-06-2 | 98.0% | 290.32 g/mol | C17H14N4O | 5 MG
Small-molecule glucocerebrosidase (GCase) modulator supplied as a 5 mg sample. It acts as an activator and non-inhibitory chaperone (reported EC50 = 0.4 μM) and contains an alkyne functional group for click chemistry.
- Modulates glucocerebrosidase activity and acts as a non-inhibitory chaperone.
- Reported EC50 = 0.4 μM in GCase assays.
- Contains an alkyne functional group for copper-catalyzed click chemistry.
- High purity (98.0%) and characterized molecular weight (290.32 g/mol).
- Provided in small-scale quantities for in vitro research applications.
Medchemexpress LLC PKC-iota inhibitor 1 | 2328094-11-5 | 99.6% | 374.44 g·mol⁻¹ | C21H22N6O | 1MG
PKC-iota inhibitor 1 is a small-molecule inhibitor of protein kinase C-iota (PKC-ι) characterized by an IC50 of 0.34 μM. It is provided as a high-purity research chemical intended for biochemical and cellular studies, including oncology-focused assays. Product documentation includes a data sheet and a safety data sheet for laboratory handling and risk information.
- Small-molecule PKC-ι inhibitor with an IC50 of 0.34 μM.
- High purity (99.6%).
- Molecular formula C21H22N6O and molecular weight 374.44 g·mol⁻¹.
- Available in multiple vial sizes for research (1 mg, 5 mg, 10 mg, 50 mg, 100 mg).
- Comes with a product data sheet and safety data sheet for handling guidance.
Cayman Chemical Ac-ANW-AMC, Purity: ≥95%, 1 mg
A fluorogenic substrate for the β5i/LMP7 subunit of the 20S proteasome; AMC is released upon enzymatic cleavage by the β5i/LMP7 subunit of the immunoproteasome and its fluorescence can be used to quantify enzyme activity; ex/em = 340-360/440-460 nm, respectively
Cayman Chemical STAT3 Transcription Factor Assay Kit, 96 Well
Cayman’s STAT3 Transcription Factor Assay Kit is a non-radioactive, sensitive method for detecting specific STAT3 DNA binding activity in nuclear extracts. As an alternative to the cumbersome electrophoretic mobility shift assay (EMSA) or the lower throughput ChIP assay, this ELISA is extremely easy to perform. This kit is an ideal way to measure STAT3 transcriptional activity downstream of cytokine or drug treatment and manipulation of cells in vitro or in vivo. Cayman’s STAT3 Transcription Factor Assay Kit detects human, mouse, rat, and non-human primate STAT3 binding on the DNA target sequence. It does not cross react with other STAT transcription factors.
Cayman Chemical Pemigatinib, Purity: ≥98%, CAS: 1513857-77-6, 5 mg
An FGFR inhibitor (IC50s = 0.4, 0.5, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively); selective for FGFR1, FGFR2, and FGFR3 over FGFR4 and KDR (IC50s = 30 and 70 nM, respectively), as well as over a panel of 56 tyrosine and serine/threonine kinases at 10 µM; reduces phosphorylation of FGFR, ERK1/2, and STAT5 in KG-1a acute myeloid leukemia cells in a concentration-dependent manner; inhibits growth in a panel of cancer cell lines expressing constitutively active FGFR (GI50s = 3-362 nM); reduces tumor growth in KATO III, KG-1, and RT-112 mouse xenograft model at 0.3 mg/kg
Cayman Chemical Z-LRGG-AMC (trifluoroacetate salt), Purity: ≥95%, 5 mg
A fluorogenic substrate for isopeptidase T; AMC is released upon enzymatic cleavage by isopeptidase T and its fluorescence can be used to quantify isopeptidase T activity; ex/em = 340-360/440-460 nm, respectively
Medchemexpress LLC PC-biotin-PEG4-NHS carbonate | 2055198-03-1 | MFCD20655073 | 97.0% | 810.87 | C35H50N6O14S | 5 MG
PC-Biotin-PEG4-NHS carbonate is a photocleavable PEG4-based biotinylation reagent with an NHS carbonate moiety that reacts with primary amines to form carbamate linkages. It is designed for affinity capture and light-controlled release of biomolecules, and can be used as a linker in chemical biology applications such as PROTAC synthesis.
- Photocleavable biotin tag enables light-controlled release of captured molecules.
- NHS carbonate reacts selectively with primary amines to form stable carbamate bonds.
- PEG4 spacer improves solubility and reduces steric hindrance.
- Suitable for affinity capture, labeling, and linker synthesis in chemical biology.
- Compatible with near-UV illumination for efficient photorelease.
Medchemexpress LLC 2-(4-chlorophenyl)thiazol-4-yl acetic acid | 17969-20-9 | 99.5% | 253.70 | C11H8ClNO2S | 10 MG
Fenclozic acid is an orally active analgesic, antipyretic, and anti-inflammatory research compound commonly used in preclinical pharmacology and biochemical assays. It is supplied as a solid and as DMSO solutions for in vitro testing and analytical characterization.
- High purity (LCMS 99.52%) for reliable experimental results.
- Characterized by LCMS and supplied with a certificate of analysis.
- Suitable for in vitro pharmacology and biochemical assays.
- Available as milligram-scale quantities and as ready-to-use DMSO solutions.
- Molecular formula C11H8ClNO2S and molecular weight 253.70 for reference.
Selleck Chemical LLC Pyrogallol 25mg 87-66-1 1,2,3-trihydroxybenzene
Pyrogallol (1,2,3-trihydroxybenzene), an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical ANTIBODY S1QEL1 1 500ug
A suppressor of IQ electron leak (IC50 = 70 nM); diminishes endogenous oxidative damage in primary astrocytes, reduces stress-induced signaling in a cardiomyocyte cell model, and protects against ischemia-reperfusion injury in perfused mouse heart
![Medchemexpress LLC N'-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine | 445430-58-0 | MFCD18089812 | 99.7% | 255.32 g·mol⁻1 | C14H17N5 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243493.png-250.jpg)
Medchemexpress LLC N'-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine | 445430-58-0 | MFCD18089812 | 99.7% | 255.32 g·mol⁻1 | C14H17N5 | 1 MG
BMS-345541 is a selective, cell-permeable small-molecule inhibitor of the catalytic subunits of IκB kinase (IKK). It inhibits IKK-2 with reported IC50 ≈ 0.3 μM and IKK-1 with IC50 ≈ 4 μM, binding at an allosteric site. The compound is used in biochemical and cellular studies to probe NF-κB signaling, inflammation, and related pathways.
- Selective inhibitor of IKK catalytic subunits.
- Potent inhibition of IKK-2 (IC50 ≈ 0.3 μM) and activity against IKK-1.
- Allosteric site binder, useful for mechanistic studies.
- Suitable for biochemical assays and cellular signaling experiments.
- High purity for reproducible results.
Medchemexpress LLC 4-(3-(5-chloro-2-methoxyphenyl)thioureido)-1-ethyl-1H-pyrazole-3-carboxamide | 957485-64-2 | 99.3% | 25 MG
FPH2 is a small-molecule research compound that induces functional proliferation of primary human hepatocytes and is used for studies of liver biology and early therapeutic development.
- Induces functional proliferation of primary human hepatocytes.
- Used for research into liver regeneration and disease models.
- High purity suitable for research applications.
- White to off-white solid for convenient handling.
- Stable when stored frozen as a powder or in solvent under recommended conditions.
- Molecular formula C14H16ClN5O2S and molecular weight 353.83 g/mol.
Medchemexpress LLC Methyl 3,4-dihydroxybenzoate | 2150-43-8 | MFCD00016437 | 1g
Methyl 3 4-dihydroxybenzoate (Protocatechuic acid methyl ester Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea Antioxidant and anti-inflammatory effect[1]
Cayman Chemical Cobicistat, Purity: ≥98%, CAS: 1004316-88-4, 25 mg
An inhibitor of CYP3A (IC50s = 30-285 nM for CYP3A metabolism of various HIV protease inhibitors); selective for CYP3A over other CYP isomers (IC50 = >25 μM for CYP1A2, 2C8, 2C9, and 2C19); does not inhibit HIV-1 protease (IC50 = >30 μM) or affect HIV replication in MT-2 cells (EC50 = >30 μM)